Scientific Advisor - ADME Project Leadership for Biologics at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Ph.D. in Biology, Cellular or Molecular Biology, Biochemistry, Pharmaceutical Sciences, Pharmacokinetics or a related scientific field
Experience in the discovery and development of biological-therapeutics highly preferred
High learning agility and a keen ability to derive and efficiently test ADME and DMPK hypotheses for novel molecules with particular emphasis on antibodies
Strong working knowledge in fundamental pharmaceutics, pharmacokinetics and ADME principles especially as they relate to biologics such as antibodies and conjugated molecules
Understanding of contemporary pharmaceutical regulatory guidance and expectations
Skills to integrate internal and external laboratory and other experimental resources through high quality scientific associations
Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to derive mechanistic understanding of drug action and performance characteristics
Additional Skills/Preferences: Industry (Pharma/Biotech) experience (1-7 years) in the preclinical evaluation of biologics and/or hybrid modalities, as well as relevant ADME project leadership experience
Onsite presence (minimum of 3 days/week) at either Indianapolis, Indiana, or Boston, Massachusetts

Responsibilities

Lead and innovate in a multidisciplinary collaborative environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly portfolio
Design and implement hypothesis driven studies to answer ADME, PK/PD and clinical pharmacology questions
Integrate ADME, PK and PK/PD endpoints with discovery biology data to define structure activity- and structure-property-relationships to guide drug delivery and optimization strategies
Engage, innovate, and collaborate with colleagues and interdisciplinary teams
Lead the preparation of regulatory communication and documents to support clinical development, new drug applications (NDA and BLA) and line extensions and interact with regulatory agencies worldwide
Build and foster relationships through coaching and mentorship with fellow scientists
Possess excellent written and verbal technical communication skills and the ability to lead, guide and influence teams in decision making

Skills

Key technologies and capabilities for this role

ADMEDMPKPharmacokineticsPharmaceuticsBiologicsAntibodiesDrug Conjugates

Questions & Answers

Common questions about this position

What is the work arrangement or location for this role?

This information is not specified in the job description.

What salary or compensation is offered for this position?

This information is not specified in the job description.

What key skills are required for the Scientific Advisor role?

Required skills include high learning agility to test ADME and DMPK hypotheses for biologics like antibodies, strong knowledge of pharmaceutics, pharmacokinetics, and ADME principles for biologics, understanding of regulatory guidance, and skills to integrate diverse data sources for mechanistic insights.

What is the company culture like at Eli Lilly's ADME team?

The ADME team is diverse, scientifically agile, and collaborative, working with biologists, chemists, and engineers in a flexible environment that supports productivity, wellness, shared learning, mutual responsibility, and career growth.

What makes a strong candidate for this Scientific Advisor position?

A high-quality candidate demonstrates high learning agility, strong ADME/DMPK knowledge for biologics, regulatory understanding, data integration skills, and the ability to lead multidisciplinary ADME studies and innovate collaboratively.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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