Protein Scientist at Twist Bioscience

Portland, Oregon, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or a related field, or M.S. with 2–5 years of relevant industry experience
Strong hands-on experience in protein purification and characterization techniques
Familiarity with analytical methods such as SEC, DLS, DSF, BLI, SPR, MS, enzymatic activity assays, among others
Background in protein chemistry (strongly preferred)
Excellent problem-solving skills, scientific judgment, and attention to detail
Strong interpersonal and communication skills with the ability to work in a collaborative, cross-disciplinary environment
Ability to troubleshoot, train, and mentor others in experimental workflows and data interpretation
Preferred Skills
Ability to multitask and thrive in a fast-paced and challenging environment
Work cross-functionally within and across the department effectively as a team player
Excellent problem-solving capabilities
Programming experience (ideally SQL, JSON, or Python) for manipulating and analyzing large datasets
Familiarity with various sequencing platforms such as Illumina NGS
Experience with various high-throughput automation platforms
Understanding of ISO 13485 and regulated environments for molecular diagnostics or NGS kits

Responsibilities

Design and implement workflows for biophysical and functional characterization of IgG and recombinant proteins, including SEC, DLS, DSF, BLI, SPR, MS, and additional downstream assays as needed
Support the transfer of protein-based workflows to production, including method optimization, documentation, and training of manufacturing staff
Lead efforts to insource protein production, including evaluation of expression systems, purification workflows, and performance benchmarking
Author technical documents, protocols, training guides, and validation reports to ensure smooth process implementation and knowledge transfer
Analyze complex experimental datasets and contribute to data-driven troubleshooting and continuous process improvement
Collaborate in cross-functional project teams representing protein science in core team meetings and contributing to strategic decisions
Document work in electronic lab notebooks and communicate results to stakeholders clearly and regularly

Skills

Key technologies and capabilities for this role

SECDLSDSFBLISPRMSprotein purificationprotein expressionbiophysical characterizationfunctional characterizationworkflow optimizationmethod developmentIgG characterization

Questions & Answers

Common questions about this position

Is this Protein Scientist role remote or onsite?

This is an onsite position in Wilsonville, OR.

What salary or compensation is offered for this role?

This information is not specified in the job description.

What qualifications and skills are required for the Protein Scientist position?

A Ph.D. in Protein Chemistry, Biochemistry, Molecular Biology, or related field (or M.S. with 2–5 years industry experience) is required, along with strong hands-on experience in protein purification and characterization techniques such as SEC, DLS, DSF, BLI, SPR, MS, and excellent problem-solving, interpersonal, and communication skills.

What is the work environment like at Twist Bioscience for this role?

The role involves working in a multidisciplinary team environment on the Tech Transfer team, collaborating cross-functionally with R&D scientists, automation & software engineers, bioinformaticists, and manufacturers in a fast-paced, innovation-driven company.

What makes a strong candidate for the Protein Scientist role?

Strong candidates thrive in multidisciplinary teams, excel at lab bench execution of varied processes, demonstrate creative problem-solving, and have a passion for delivering high-quality results with careful experimental execution, particularly with hands-on protein expertise.

Twist Bioscience

Produces synthetic DNA for biotechnology applications

About Twist Bioscience

Twist Bioscience specializes in creating synthetic DNA for applications in biotechnology, pharmaceuticals, and research. Their proprietary platform allows for the quick and accurate production of DNA sequences, providing clients with products like genes, oligo pools, and variant libraries. The company stands out by offering high-quality DNA at competitive prices, making them a valuable partner for academic institutions and pharmaceutical companies. Twist Bioscience aims to support advancements in personalized medicine and biotechnology through their innovative DNA synthesis solutions.

South San Francisco, CaliforniaHeadquarters

2013Year Founded

$236.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Disability Insurance

Life Insurance

401(k) Retirement Plan

Risks

Increased competition from Ginkgo Bioworks may impact Twist's market share.

Dependency on AI technologies could pose integration and operational challenges.

New CIO appointment may lead to transitional challenges in IT strategy and operations.

Differentiation

Twist Bioscience uses a unique silicon-based DNA synthesis platform for precision and scale.

They offer high-quality DNA sequences at competitive prices, attracting diverse clients.

Their proprietary platform provides instant feedback on DNA sequence synthesis feasibility.

Upsides

Growing demand for synthetic DNA in personalized medicine boosts Twist's market potential.

Collaboration with Absci leverages AI to accelerate antibody discovery and drug development.

Synthetic biology market projected to grow at 28.8% CAGR, benefiting Twist's growth.

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