Manager, CMC Operations at Relay Therapeutics

Cambridge, Massachusetts, United States

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Not SpecifiedCompensation

Junior (1 to 2 years), Mid-level (3 to 4 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

Bachelor’s degree in life sciences, engineering, business, or a related field
3 to 5 years of experience in CMC operations, technical operations, or pharmaceutical manufacturing within a biotech or pharmaceutical company
Experience supporting clinical-stage programs and working with CDMOs
Working knowledge of GMP, ICH guidelines, and regulatory expectations for CMC development
Strong project management, organizational, and communication skills
Detail-oriented and proactive, with the ability to anticipate and resolve issues
Collaborative mindset with the ability to work effectively within cross-functional teams
Comfortable operating in a dynamic environment with evolving priorities

Responsibilities

Collaborate with CMC, Accounting, and Finance teams to support the creation and maintenance of department budgets and forecasts
Generate and finalize all departmental Purchase Orders (POs) within the Coupa system; track progress to ensure timely approval
Confirm that all PO requests are accurately captured in the budget; escalate and obtain approval for any items not previously included
Ensure contracts contain appropriate legal language, milestones, and payment terms
Track CMC operational expenses against budget by conducting monthly reviews of accruals in partnership with CMC functional leads (Drug Substance, Drug Product, Analytical Development, Quality, and Clinical Supply) and Finance
Support the onboarding of new CMC and supply chain vendors
Meet with vendors monthly (or as needed) to monitor spending against approved contracts
Coordinate internal and external vendor communications and action items, including contract and PO management, budget and accrual oversight, material transfers, and inventory system support
Support the execution of CMC activities across Drug Substance, Drug Product, Analytical Development/Manufacturing, and Clinical Supply Chain, including scheduling and project management tasks
Assist in the development and alignment of CMC project plans, risk assessments, and timelines with overall program goals; ensure timely communication of project status, timeline changes, cost updates, and risks to team members and functional leaders
Facilitate internal CMC team meetings, track action items, and maintain documentation to drive operational excellence
Contribute to continuous improvement efforts across CMC processes, tools, and data management systems

Skills

Key technologies and capabilities for this role

CMC OperationsProject ManagementBudget ManagementPurchase OrdersCoupaVendor ManagementContract ManagementAccrualsSupply ChainPharmaceutical Development

Questions & Answers

Common questions about this position

What education is required for the Manager, CMC Operations role?

A Bachelor’s degree in life sciences, engineering, business, or a related field is required.

What experience is needed for this position?

3 to 5 years of experience in CMC operations, technical operations, or pharmaceutical manufacturing within a biotech or pharmaceutical company is required, including experience supporting clinical-stage programs and working with CDMOs, along with working knowledge of GMP and ICH guidelines.

What are the key skills for success in this role?

Strong project management and operational execution skills are essential, along with the ability to navigate complex, cross-functional deliverables in a clinical-stage biotech environment.

Is this role remote or office-based?

This information is not specified in the job description.

What is the salary or compensation for this position?

This information is not specified in the job description.

Relay Therapeutics

Biotech company focused on drug discovery

About Relay Therapeutics

Relay Therapeutics focuses on drug discovery by studying protein motion to develop new treatments for complex diseases. Their main tool, the Dynamo™ platform, uses both experimental and computational methods to identify potential drug candidates, especially for conditions that are hard to treat with current therapies. This platform allows them to target proteins that have previously been difficult to address, particularly in areas like precision oncology and genetic diseases. Unlike many competitors, Relay Therapeutics emphasizes the importance of protein dynamics in their research, which sets them apart in the biotech field. Their goal is to create effective medicines that can significantly improve patients' lives, and they are actively conducting clinical trials to ensure the safety and effectiveness of their drug candidates.

Cambridge, MassachusettsHeadquarters

2016Year Founded

$535MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

201-500Employees

Benefits

Medical, dental, vision

Life, disability, & FSA

401k

Commuter benefits

Parental leave

Home office stipend

Tuition reimbursement

PTO

Risks

Increased competition from VantAI threatens Relay's market position.

Layoffs may impact Relay's operational efficiency and research progress.

Reliance on public offerings suggests potential financial instability for Relay.

Differentiation

Relay's Dynamo platform targets previously undruggable proteins, expanding treatment possibilities.

Focus on protein motion places Relay at the forefront of innovative drug discovery.

Relay's precision oncology approach tailors treatments to individual genetic profiles.

Upsides

AI-driven drug discovery complements Relay's computational techniques, enhancing drug development.

Quantum computing integration could boost Dynamo's capabilities in drug discovery.

Rising personalized medicine trend aligns with Relay's precision medicine focus.

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