Graduate Research Intern - Machine Learning for Protein Structure Prediction

Position Overview

• Location Type: Remote
• Job Type: Part-Time
• Salary: Not specified
• Internship Duration: Fall 2025
• Brief Description: Iambic Therapeutics is seeking a graduate student for a research internship to contribute to the development of NeuralPLexer, a protein structure prediction platform. This internship focuses on cutting-edge machine learning approaches for structural biology, particularly understanding protein conformational dynamics and affinity. It’s a collaborative opportunity to develop next-generation methods combining deep learning with physics-based approaches.

Requirements

• Education:
  • Currently enrolled in a PhD program in Computational Chemistry, Computational Biophysics, Computer Science, Computational Biology, or related field.
• Skills:
  • Proficiency in Python
  • Experience with enhanced sampling and classical molecular dynamics simulations
  • Experience with deep learning frameworks (PyTorch preferred)
  • Understanding of protein structure and protein dynamics

Responsibilities

• Develop and train deep learning models for protein structure prediction.
• Work with molecular dynamics simulations and enhanced sampling techniques to validate and improve model predictions.
• Analyze large-scale protein structural data to identify patterns in conformational changes.
• Assist in implementing new model architectures and training strategies.
• Contribute to the model evaluation framework, particularly for conformational accuracy.
• Participate in team meetings and present findings to the computational group.

Learning Opportunities

• Work with state-of-the-art protein structure prediction models.
• Learn to integrate physical principles into machine learning approaches.
• Gain experience with enhanced sampling methods.
• Understand real-world applications in drug discovery.
• Collaborate with experts in both ML and computational chemistry.

About Iambic Therapeutics

• Founded: 2019
• Headquarters: San Diego, California
• Description: Iambic Therapeutics is disrupting the therapeutics landscape with its AI-driven drug-discovery platform. The company has assembled a world-class team uniting AI experts and experienced drug hunters. The Iambic platform is delivering high-quality, differentiated therapeutics to clinical stage with unprecedented speed and across multiple target classes and mechanisms of action. They are advancing an internal pipeline of clinical assets to address urgent unmet patient needs.
• Website: iambic.ai

Mission & Core Values

• Mission: To deliver better medicines through innovations in AI-based discovery technologies.