Axsome Therapeutics Inc

Graduate Research Intern - Machine Learning for Protein Structure Prediction

United States

Not SpecifiedCompensation
InternshipExperience Level
Part TimeJob Type
UnknownVisa
Biotechnology, Pharmaceuticals, Computational BiologyIndustries

Requirements

The candidate must be currently enrolled in a PhD program in Computational Chemistry, Computational Biophysics, Computer Science, Computational Biology, or a related field, and possess experience with Python, enhanced sampling and classical molecular dynamics simulations, and deep learning frameworks such as PyTorch. A foundational understanding of protein structure and protein dynamics is also required, along with an interest in scientific machine learning applications.

Responsibilities

The Graduate Research Intern will assist in developing and training deep learning models for protein structure prediction, working with molecular dynamics simulations and enhanced sampling techniques to validate model predictions, analyze large-scale protein structural data to identify patterns, contribute to implementing new model architectures and training strategies, and participate in model evaluation, presenting findings to the computational group and collaborating with experts in ML and computational chemistry.

Skills

Python
Enhanced sampling
Molecular dynamics simulations
Deep learning frameworks
PyTorch
Protein structure
Protein dynamics

Axsome Therapeutics Inc

Develops therapies for CNS disorders

About Axsome Therapeutics Inc

Axsome Therapeutics develops therapies for central nervous system (CNS) disorders, focusing on conditions like major depressive disorder, treatment-resistant depression, and Alzheimer's agitation. Their main product, AXS-05, is an oral medication that works by blocking NMDA receptors in the brain, which helps regulate mood. This drug has shown positive results in clinical trials and has received special FDA status to speed up its approval process. Unlike many competitors, Axsome emphasizes addressing unmet medical needs in CNS disorders and aims to improve patient outcomes through rigorous research and development. The company's goal is to bring effective treatments to market, enhancing the quality of life for patients suffering from these conditions.

Key Metrics

New York City, New YorkHeadquarters
2012Year Founded
$430.7MTotal Funding
IPOCompany Stage
Biotechnology, HealthcareIndustries
201-500Employees

Benefits

Performance Bonus
Company Equity

Risks

Increased competition from companies like Compass Pathways in the CNS market.
Potential delays in AXS-07 launch amid growing market anticipation.
Departure of key personnel like Lori Englebert may impact strategic direction.

Differentiation

Axsome focuses on CNS disorders with limited current treatment options.
AXS-05, an NMDA receptor antagonist, targets major depressive disorder and treatment-resistant depression.
Axsome's balanced portfolio includes both clinical and research stage products.

Upsides

FDA's fast-tracking of CNS treatments could expedite Axsome's drug approvals.
Increased investment in CNS R&D drives innovation, benefiting Axsome's pipeline.
Growing personalized medicine trend offers Axsome opportunities for tailored therapies.

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