Downs Stream Application Scientist at Thermo Fisher Scientific

Hyderabad, Telangana, India

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biopharmaceuticals, BiotechnologyIndustries

Requirements

Ph.D., M.S., or B.S. in Biotechnology, Biochemical Engineering, Molecular Biology, or a related field with a focus on cell culture and upstream processing
3+ years of experience in upstream process development for biologics, including hands-on experience with mammalian or microbial cell culture systems
Proficiency in working with single-use bioreactor systems (highly preferred)
Familiarity with fed-batch, perfusion, and continuous culture processes
Solid understanding of bioreactor design, operation, and process control strategies
Proficiency with process monitoring tools and analytical instrumentation for cell culture
Excellent problem-solving and analytical skills with the ability to manage sophisticated data sets
Strong written and verbal communication skills, with experience communicating technical data to diverse audiences
Experience with cGMP guidelines, regulatory standards, and technology transfer in biomanufacturing
Knowledge of cell line development and characterization
Familiarity with automation, PAT (Process Analytical Technology), and data-driven optimization tools
Ability to lead numerous projects simultaneously and meet aggressive timelines
Demonstrated ability to lead multiple collaborators and conflicting goals
Business-level proficiency in English (verbal/written) and proficiency in Excel and presentation skills
Willingness to travel as required
Self-motivated, team-oriented, collaborative

Responsibilities

Develop and optimize Downstream processes, including chromatography process for customer projects or inhouse process development
Perform small-scale, bench-scale, and pilot-scale experiments to support process development and solving
Assess and incorporate resin technologies to enhance process flexibility and efficiency
Design and complete experiments to enhance cell growth, productivity, and product quality attributes
Lead downstream process technology transfer to clinical and commercial manufacturing scales
Develop and document detailed process descriptions, standard operating procedures (SOPs), and batch records for scale-up activities
Collaborate with manufacturing to ensure smooth implementation of upstream processes in single-use production systems
Analyze experimental data to evaluate process performance, identify trends, and recommend improvements
Prepare technical reports, presentations, and documentation for internal and external collaborators, following Good Documentation Practices (GDP)
Maintain accurate records of process development activities and experimental results in electronic lab notebooks (ELNs)
Work closely with downstream processing, analytical development, quality assurance, and regulatory teams to ensure seamless integration into end-to-end biomanufacturing workflows
Participate in project meetings and contribute to strategy discussions, ensuring alignment with organizational goals and timelines
Support solving and resolution of upstream-related challenges during production
Stay informed on advancements in cell culture technologies, single-use systems, and bioprocessing methodologies
Identify and implement innovative approaches to improve upstream process efficiency, scalability, and sustainability
Actively contribute to fostering a culture of innovation and continuous improvement within the Bioprocess Design Center

Skills

Downstream Processing

Chromatography

Purification

Mammalian Systems

Microbial Systems

Resin Technologies

Scale-Up

Technology Transfer

SOPs

Batch Records

ELNs

GDP

Data Analysis

Thermo Fisher Scientific

Provides life sciences products and services

About Thermo Fisher Scientific

Thermo Fisher Scientific offers a variety of products and services that support scientific research and healthcare, including laboratory equipment, reagents, and software solutions. Their products are used in applications like protein biology, real-time PCR, and sequencing, serving clients such as academic institutions and pharmaceutical companies. Unlike competitors, Thermo Fisher emphasizes customer support and education, helping clients optimize their experiments. The company's goal is to be a leading provider of life sciences solutions that contribute to a healthier and safer world.

Waltham, MassachusettsHeadquarters

1956Year Founded

$17MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Increased competition in single-use bioprocessing may impact market share.

Sale of anatomical pathology business could create a temporary product gap.

Investment in miDiagnostics may face regulatory challenges affecting returns.

Differentiation

Thermo Fisher offers a comprehensive range of life sciences products and services.

Their well-known brands include Thermo Scientific, Applied Biosystems, and Invitrogen.

They provide strong customer support and educational resources to optimize client workflows.

Upsides

Expansion of biologics production facility enhances capacity for precision biologics monitoring.

Investment in miDiagnostics aligns with demand for rapid diagnostic solutions in BioPharma.

Collaboration with Mainz Biomed positions them in the growing cancer detection market.

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