Advisor/Senior Advisor Downstream Purification Development at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

Ph.D. in Biochemistry, Chemistry, or related field
General knowledge and understanding of issues associated with scaling of protein purification processes and use

Responsibilities

Lead the design, execution and interpretation of appropriate purification development experiments to drive the definition and optimization of downstream processes for the generation of recombinant protein active pharmaceutical ingredients
Use first principles and designed experiments (DOE) to predict/understand/control the impact of physical and chemical processing conditions on recombinant protein product quality
Lead the development of validated scaled-down models of key bioprocess unit operations including: filtration/TFF, chromatography operations and freeze/thaw
Participate in and/or lead cross-functional process development teams and effectively collaborate with other groups in Bioprocess and Bioproduct Development, Discovery, Technical services for Manufacturing and Manufacturing
Support transfer of purification processes to Technical services for Manufacturing laboratories and pilot plant/manufacturing sites
Authorship of technical reports and regulatory documents
Work effectively with external parties on development projects, research collaborations and outsourcing efforts
Lead/support implementation of organizational strategic initiatives in support of the Lilly pipeline
Keep abreast of relevant scientific literature and new technologies/capabilities and regulatory initiatives/requirements. Lead implementation, as appropriate
Leverage internal and external influence to solve problems and benchmark potential solutions
Provide coaching, training and administration of performance management to personnel (primarily, but not limited to, direct reports)
Ensure work and team activities are aligned with all relevant Development Quality, regulatory, HSE, GLP and GMP requirements

Skills

Downstream Purification

Process Development

Purification Processes

Recombinant Proteins

Process Control Strategy

Process Scale-up

Technology Transfer

Bioprocess Engineering

Bioconjugation

Antibody-Drug Conjugates

mAbs

Pilot Plant

Manufacturing

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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