Advisor/Senior Advisor, Analytical Chemistry -Antibody-Drug Conjugates at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Experience across multiple analytical techniques
Aptitude in technical problem-solving
Ability to work both independently and collaboratively in a dynamic environment
Experience in analytical development for antibody-drug conjugates (ADCs), with focus on linker-payload components
Learning agility and ability to apply scientific principles across multiple domains (e.g., organic chemistry, pharmaceutical sciences, PAT, and large molecule analytics)

Responsibilities

Develop and validate analytical methods for ADC linker-payload components; establish specifications, characterize impurities and degradation pathways, and support comparability studies
Define control strategies and testing plans for linker-payloads, raw starting materials, and in-process intermediates
Drive implementation of analytical solutions and strategies to enable synthetic chemistry and process engineering needed to enable ADC linker-payload development and manufacturing
Collaborate across functions to deliver robust control strategies for drug-linker intermediates and conjugated drug substances/products
Provide technical oversight for analytical development work executed internally and by external partners (CROs/CMOs); ensure sound method development, characterization, and successful technology transfer
Contribute to regulatory submissions (CTD authoring, NDA/BLA filings), support pre-approval inspections (PAI), and respond to regulatory agency questions (RtQs)
Mentor and develop scientific staff; support continued professional growth, knowledge sharing, and technical excellence
Plan and manage both short- and long-term development activities; define project timelines, allocate resources, monitor progress, and adjust plans as needed
Partner with development and manufacturing teams to provide clinical and regulatory deliverables
Promote an inclusive culture by embracing diverse perspectives and encouraging innovation
Engage externally to identify and apply relevant advances in analytical chemistry and drug development

Skills

Analytical Chemistry

Antibody-Drug Conjugates

CMC

HPLC

Mass Spectrometry

Spectroscopy

Chromatography

Pharmaceutical Analysis

Technical Problem-Solving

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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