ADME Project Leadership for Genetic Medicines at Eli Lilly and Company

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific field
Greater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PD
High learning agility and a keen ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel molecules
Strong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles - especially as they relate to novel genetic medicine therapeutic modalities
Understanding of pharmaceutical regulatory guidance and expectations
Agile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to interpret complex data sets and to derive mechanistic understanding of drug action and ADME/DMPK characteristics

Responsibilities

Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolio
Design, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questions
Integrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies
Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teams
Lead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authorities
Mentor and support junior scientists and build relationships through coaching and mentorship with fellow scientists at all levels

Skills

Key technologies and capabilities for this role

ADMEDMPKsiRNAASOmRNAgene editinggene therapyhypothesis testing

Questions & Answers

Common questions about this position

What location is this position based at?

The position is at Lilly's expanding Boston campus.

What key skills are required for this ADME Project Leadership role?

Required skills include high learning agility to test ADME and DMPK hypotheses, strong knowledge of pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles for genetic medicines, understanding of regulatory guidance, and ability to interrogate diverse data for mechanistic insights.

What is the company culture like at Eli Lilly for this team?

The diverse and agile ADME team collaborates closely with biologists, chemists, engineers, and other R&D functions, supports each other through shared learning and collective responsibility, and fosters professional growth while advancing science.

What compensation or salary information is provided?

This information is not specified in the job description.

What makes a strong candidate for this role?

A high-quality candidate demonstrates high learning agility, strong ADME/DMPK knowledge for genetic medicines, regulatory understanding, data interrogation skills, and the ability to lead multidisciplinary teams with innovative thinking.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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