Senior Principal Scientist - Preclinical at Eli Lilly and Company

Toronto, Ontario, Canada

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

PhD degree in oncology, immunology, biology, or similar scientific field
Demonstrated success independently designing experiments and planning multiple concurrent scientific projects (preferred: 1-2 years of post-degree experience)
Strong experience with mammalian cell culture and aseptic techniques, including management of numerous cell lines simultaneously
Strong experience with flow cytometry, including independently validating and designing stain panels, sample preparation for staining, and interpretation of flow cytometry data
Experience in animal handling, tumor cell implantation for developing in-vivo tumor models, tumor measurements, compound formulation and intravenous injections and necropsy
Excellent organization, problem-solving and decision-making skills
Strong interpersonal skills and confidence in working in a fast-paced, team environment
Experience with Graphpad Prism, Flowjo and MS office
Highly motivated and passionate about scientific research
Adaptable and able to thrive in a fast-paced environment
Innovative thinker with a proactive approach to problem-solving

Responsibilities

Independently design, execute and interpret data from multiple overlapping in-vivo pharmacology studies to support radioligand therapy development
Perform routine tissue culture of numerous mammalian cell lines simultaneously, including passaging, pathogen testing, and preparation for engraftment
Collaborate with chemistry, preclinical, translational and animal facility team members to obtain necessary materials and documentation for efficient execution of in vivo studies
Critically assess data and methods, adapting and adjusting procedures as necessary
In conjunction with managers, establish priorities and meet timelines for key experiments
Provide clear communication of scientific data to co-workers through internal presentations and written methods
Perform flow cytometry to analyze cell populations from in vitro and ex-vivo samples
Interface with external vendors and partners to support early discovery activities

Skills

Key technologies and capabilities for this role

in vivo pharmacologymammalian tissue culturetumor cell engraftmentflow cytometryradioligand therapyexperimental designdata interpretationcell passagingpathogen testing

Questions & Answers

Common questions about this position

What is the salary or compensation for this Senior Principal Scientist role?

This information is not specified in the job description.

Is this position remote or does it require working on-site?

This information is not specified in the job description.

What are the key skills required for this role?

The role requires a PhD in oncology, immunology, biology or similar, strong experience with mammalian cell culture and aseptic techniques including managing multiple cell lines, strong experience with flow cytometry including designing stain panels and data interpretation, and experience in animal handling and tumor cell implantation.

What is the company culture like at Eli Lilly?

Eli Lilly unites caring with discovery to make life better for people, puts people first, and seeks determined individuals who give their best effort while contributing to communities through philanthropy and volunteerism.

What makes a strong candidate for this Senior Principal Scientist position?

A strong candidate will have a PhD in a relevant field plus 1-2 years post-degree experience, demonstrated success independently designing experiments and managing multiple projects, and expertise in mammalian cell culture, flow cytometry, and in vivo tumor models.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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