Scientist/Senior Scientist, LNP Discovery at Prime Medicine

Cambridge, Massachusetts, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8 years, MS+6 years)
Experience with lipid nanoparticle (LNP) formulation, QC, and characterization techniques
Hands-on experience with mouse handling, dosing, and tissue collection; intratracheal delivery (e.g., broncoscope) strongly preferred
Familiarity/experience with molecular biology techniques (e.g., qPCR, DNA sequencing, mammalian cell culture, and flow cytometry preferred)
Strong organizational and critical thinking skills, attention to detail
Ability to work both independently and as part of a collaborative team
Excellent communication and interpersonal skills to thrive in a cross-functional setting
Onsite 5 days a week in Cambridge, MA

Responsibilities

Design and formulate LNPs using microfluidics; characterize using DLS, zeta potential, pKa, and Ribogreen assays
Execute and support in vivo studies focused on pulmonary delivery of LNP formulations including intratracheal delivery in preclinical models
Collaborate with internal teams on study design, execution, data collection, and interpretation
Support downstream analyses using flow cytometry and molecular biology techniques
Collaborate cross-functionally to integrate in vivo findings into delivery platform development
Present data in written reports and oral presentations

Skills

Key technologies and capabilities for this role

LNP formulationLNP characterizationin vivo deliverymouse modelspulmonary deliveryPrime Editor RNAnon-viral deliverygene editing

Questions & Answers

Common questions about this position

Is this role remote or onsite?

The ideal candidate will be onsite 5 days a week in Cambridge, MA.

What are the required qualifications for this position?

A PhD in Biomedical/Chemical Engineering, Biochemistry, or related field with 0-2 years of relevant experience (or BS+8, MS+6) is required.

What key skills and experience are needed for the Scientist/Senior Scientist role?

Expertise in lipid nanoparticle (LNP) formulation, QC, and characterization techniques is required, along with experience in in vivo studies using mouse models for pulmonary delivery.

What is the work environment like at Prime Medicine?

The role is within a collaborative, interdisciplinary cross-functional program team focused on fast-paced, exciting projects developing genetic editing technologies.

What makes a strong candidate for this LNP Discovery role?

Candidates with hands-on experience in LNP formulation using microfluidics, in vivo pulmonary delivery studies in mouse models, and a passion for genetic editing technologies will stand out.

Prime Medicine

Gene editing technology for genetic diseases

About Prime Medicine

Prime Medicine focuses on gene editing, specifically using a technology called Prime Editing to make precise changes to DNA. This technology can identify and fix faulty DNA segments, which helps restore normal genetic function. The company aims to cure, halt, or prevent genetic diseases, providing long-term benefits to patients. Prime Medicine targets individuals with genetic disorders, a significant market globally. Unlike many competitors, it emphasizes collaboration with research institutions and pharmaceutical companies to advance its technology and bring it to market through licensing agreements and partnerships. The leadership team has extensive experience in developing innovative medicines, and the company is committed to enhancing its technological capabilities.

Cambridge, MassachusettsHeadquarters

2019Year Founded

$306.4MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

201-500Employees

Benefits

Flexible Work Hours

Risks

Intellectual property disputes may lead to costly legal battles and delays.

The competitive landscape in gene editing is intensifying, challenging Prime Medicine's market position.

Reliance on partnerships exposes Prime Medicine to risks if collaborations don't meet expectations.

Differentiation

Prime Editing offers precise DNA modifications without double-stranded breaks, unlike CRISPR.

Prime Medicine's technology can correct faulty DNA segments, restoring normal genetic function.

The company collaborates with top-tier partners like Bristol Myers Squibb for strategic growth.

Upsides

Prime Medicine secured $244.6M to advance its genetic therapies and pipeline.

The partnership with Bristol Myers Squibb includes potential milestone payments over $3.5 billion.

Growing interest in gene editing for rare diseases boosts investment and collaboration opportunities.

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