Scientist/Senior Scientist – Discovery RLT at Eli Lilly and Company

Toronto, Ontario, Canada

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Not SpecifiedCompensation

Junior (1 to 2 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

B.Sc. or M.Sc. in biochemistry, biology, chemistry, pharmacy, or related discipline
3+ years relevant postgraduate experience (industry preferred)
Demonstrated success independently designing experiments and analyzing scientific data
Experience performing in vitro biochemical/biophysical assays
Experience with mammalian cell culture and aseptic techniques
Strong background in performance of cell-based reporter assays and cytotoxicity assays
Familiarity with protein analysis and purification methods
Ability to communicate scientific data effectively to an interdisciplinary team
Excellent problem-solving and decision-making skills
Working knowledge of MS Office, Graphpad Prism, and ChemDraw

Responsibilities

Independently perform routine biochemical and/or cell-based assays to characterize the activity of early-stage ligands, including enzymatic activity assays, cytotoxicity assays, ELISAs, and functional reporter assays
Passage and prepare mammalian cells to be used in assays and in vivo studies
Determine binding affinity and kinetic parameters of protein-ligand interactions through biophysical techniques (SPR, BLI, DSF)
Perform conjugation and purification of protein-based ligands by FPLC
Assist with sample processing (serum, tissue samples, etc) to support biodistribution and metabolite profiling
Interface with external vendors to support early discovery activities
Critically assess data and methods, adapting and adjusting procedures as necessary
Fully adhere to Lilly Discovery Quality standards
In conjunction with managers, establish priorities and meet timelines for key experiments
Provide clear communication of scientific data to co-workers through internal presentations and written methods

Skills

Biochemical Assays

Cell Culture

Protein Conjugation

Purification Methods

Enzymatic Activity Assays

Cytotoxicity Assays

ELISA

Functional Reporter Assays

SPR

BLI

DSF

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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