Postdoctoral Fellow at Cytokinetics

South San Francisco, California, United States

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Not SpecifiedCompensation

Junior (1 to 2 years)Experience Level

Full TimeJob Type

UnknownVisa

Biopharmaceutical, Biotechnology, CardiovascularIndustries

Requirements

PhD in computational biology, computer science, bioinformatics, human genetics, or related field
Demonstrated expertise in multidimensional data analysis
Previous experience analyzing multimodal data from population biobanks such as UK Biobank, All of Us, FinnGen or Genomics England is highly desired
Proven experience applying AI/ML techniques to biological problems (whether through academic research or personal side projects) is highly valued
Well-articulated career goals in research (biotech or academia)
Track record for research excellence, independent critical thinking, and the ability to design, execute, and interpret experiments as demonstrated by high quality publications, presentations, fellowships, and grants
Enthusiasm for working in a team-based, multi-disciplinary environment, paired with excellent verbal and written communication skills
Clear commitment to a rigorous 1-2 year research and enrichment program that includes stipend for travel to a scientific conference and external training/coursework beyond the career training received from mentors and colleagues

Responsibilities

Spearhead a computational biology project to harmonize multi-modal clinical and imaging data across the UK Biobank and All of Us population biobanks related to human skeletal muscle function
Employ machine learning and deep learning approaches to categorize skeletal muscle phenotypes that can then be correlated to genetic variation, validated with clinical disease diagnosis and severity scores
Work collaboratively with research mentor with the goal of generating a high impact publication on creation of this new tool
Play an integral role in championing new bioinformatic tools and workflows that enable discovery of novel therapeutic targets for drug discovery
Conduct research both independently and in a collaborative team-based setting
Provide regular project updates and progress in small and large group settings
Provide scientific and technical expertise to advance discovery programs

Skills

Computational Biology

Machine Learning

Deep Learning

Multi-Modal Data

Clinical Data

Imaging Data

Biobank Analysis

Phenotyping

Data Harmonization

Skeletal Muscle Biology

Cytokinetics

Develops drugs for muscle function disorders

About Cytokinetics

Cytokinetics focuses on developing medicines that improve muscle function for patients with cardiovascular and neuromuscular diseases. Their products are small molecule drugs designed to either enhance or inhibit muscle function, tailored to specific therapeutic needs. The company has a pipeline of drugs, including omecamtiv mecarbil and reldesemtiv, which are in various stages of clinical trials. Unlike many competitors, Cytokinetics emphasizes rigorous scientific research and has conducted over 50 clinical trials to ensure the effectiveness of its treatments. The goal is to bring new therapies to market that address the unmet needs of patients suffering from conditions like heart failure, ALS, and HCM.

South San Francisco, CaliforniaHeadquarters

1998Year Founded

$58.4MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

501-1,000Employees

Risks

Increased competition could impact market share and profitability.

Potential delays in clinical trials could hinder drug commercialization.

Dependence on strategic partnerships may expose Cytokinetics to risks if challenges arise.

Differentiation

Cytokinetics focuses on muscle activators and inhibitors for cardiovascular and neuromuscular diseases.

The company has a robust pipeline including omecamtiv mecarbil and aficamten.

Cytokinetics engages in strategic partnerships, like with Sanofi, to expand market reach.

Upsides

Recent investments indicate strong interest in muscle activators and inhibitors.

Strategic partnerships, like with Sanofi, expand market reach and potential revenue.

Significant funding from Royalty Pharma supports commercial launch and R&D advancements.

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