Pliant Therapeutics

Develops treatments for fibrotic diseases

San Francisco, California, United States

About Pliant Therapeutics

Pliant Therapeutics develops treatments for fibrotic diseases, which cause thickening and scarring of connective tissue, leading to organ dysfunction. Their products work by targeting the biological mechanisms behind fibrosis, particularly through the inhibition of integrins, proteins that help cells stick together and communicate. This focus allows Pliant to create specific and effective therapies for various fibrotic conditions. Unlike many competitors, Pliant emphasizes a deep understanding of fibrosis and integrin biology, which informs their drug development process. The company's goal is to stop the progression of fibrotic diseases and restore normal organ function, ultimately improving the lives of patients affected by these conditions.

San Francisco, CaliforniaHeadquarters
2015Year Founded
$201.4MTotal Funding
IPOCompany Stage
Biotechnology, HealthcareIndustries
51-200Employees

Benefits

Health Insurance
Dental Insurance
Vision Insurance
Life Insurance
Disability Insurance
401(k) Company Match
Remote Work Options
Flexible Work Hours
Professional Development Budget
Wellness Program
Mental Health Support
Gym Membership
Phone/Internet Stipend
Home Office Stipend
Paid Vacation
Paid Sick Leave
Paid Holidays
Parental Leave
Family Planning Benefits
Fertility Treatment Support
Employee Stock Purchase Plan
Performance Bonus
Relocation Assistance
Employee Referral Bonus
Student Loan Assistance
Adoption Assistance
Childcare Support
Elder Care Support
Pet Insurance
Bereavement Leave
Commuter Benefits
Meal Benefits
Legal Services
Employee Discounts
Company Social Events

Risks

New executive appointments may lead to strategic shifts or internal disruptions.
Recruitment challenges for BEACON-IPF trial due to competition for patient enrollment.
Early-stage trials for PLN-101095 carry high risks of failure or adverse effects.

Differentiation

Pliant focuses on integrin inhibitors for fibrotic diseases, a unique therapeutic approach.
PLN-74809 targets both IPF and PSC, offering dual treatment potential.
Partnership with Novartis enhances Pliant's capabilities in liver fibrosis treatment.

Upsides

Orphan Drug Designation for PLN-74809 offers market exclusivity and financial incentives.
Positive interim data from INTEGRIS-PSC trial suggests promising efficacy for bexotegrast.
Global recruitment for BEACON-IPF trial could enhance international presence and data diversity.