Chroma Medicine

Develops single-dose genomic medicines using epigenetics

Boston, Massachusetts, United States

About Chroma Medicine

Chroma Medicine develops single-dose genomic medicines that utilize epigenetics to regulate gene expression. By altering the structure of chromatin, the material that carries DNA, the company aims to create treatments that can lead to lasting changes in how genes are expressed, even as cells divide. This method allows for the control of gene expression without changing the DNA sequence itself, which could transform the treatment landscape for various diseases. Unlike many competitors, Chroma Medicine focuses specifically on this epigenetic approach, positioning itself in the biotechnology market with a unique business model centered on research and development. The goal is to create a new class of therapeutics that can effectively address diseases while also expanding the field of genomic medicine.

Boston, MassachusettsHeadquarters
2021Year Founded
$252.9MTotal Funding
SERIES_BCompany Stage
Biotechnology, HealthcareIndustries
51-200Employees

Risks

Integration with Nvelop Therapeutics may dilute Chroma's brand identity.
Staff layoffs suggest potential financial strain or strategic pivots.
Reliance on early-stage technologies like CHARM poses clinical outcome risks.

Differentiation

Chroma Medicine uses epigenetic editing to regulate gene expression without altering DNA.
Their CHARM technology recruits DNA methyltransferases for durable gene silencing.
Chroma's approach avoids DNA cutting, reducing risks of unintended genomic changes.

Upsides

Chroma's PCSK9 silencing shows potential in cardiovascular disease therapeutics.
Their multiplex editing enhances CAR T cells, improving cancer immunotherapy.
Partnerships and funding are bolstered by interest in epigenetic therapies.